In this talk, Dr. Liwen Shih will take you through the amazing Q/AI/HPC journey on Quantum Optimization, Heterogeneous Computing, Complex Bioinformatics, Adaptive Image Processing, Computer–Aided Diagnosis, Material Design, Tele/Mobile-Operation, Space Radiation/Debris, Functional Health, Seismic Earthquake Wave Propagation, Wildfire Detection, Sustainable Green Ecosystem, Low-Impact Permaculture, and tackling other complex Biomed, Aerospace, Seismic, Energy, Environment, Games/Puzzles/Creativity, Social and Engineering challenges.